In recent years, scientists have made huge gains in their understanding of how genes can be altered and transferred from one organism to another – but that knowledge has been acquired amidst controversy and concern. The deep ethical concerns that have resulted from the emergence of genetic manipulation are explored in this course. We begin with an examination of the basic structure and function of genes.

A number of pioneering examples and techniques are explored, helping to explain why our present-day view of genetic manipulation can combine feelings of optimism and unease. Examples are drawn from both plants (notably GM crops) and animals (including Dolly the sheep), with a special emphasis on the implications of promising medical techniques such as gene therapy. Our hope is that by exploring the science ‘behind the headlines’, and its interactions with the equally complex social factors, we will acquire a clearer idea of both what is possible and what may be desirable.

Learning outcomes

After studying this course, you should be able to:

  • understand more about the science that underlies the development of genetically modified organisms and in particular how gene transfer is brought about
  • know something of the potential benefits and uncertainties associated with gene transfer and the high levels of technical ingenuity involved
  • understand more the science that underpins the development of Golden Rice and understand why the usefulness of this product has proved so contentious.


Course Curriculum

1. Genetic manipulation of plants
Genetic manipulation of plants and GM crops: an introduction 01:30:00
2. Genetic modification of plant cells
Crown gall disease: genetic engineering in nature 01:30:00
Using A. tumefaciens to genetically modify plant cells 01:30:00
From infected cells to transgenic plants 00:30:00
3. Common traits introduced by GM
Insect resistance 01:30:00
Herbicide tolerance 01:30:00
4. Golden Rice: a case study
Vitamin A deficiency 01:30:00
The science behind Golden Rice 01:30:00
Golden Rice in the public domain 01:30:00
The ongoing story 01:30:00
Summary – Genetic Modification 01:30:00
Acknowledgements – Genetic Modification 00:20:00
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