What you should know about Genetic Risk

Genes (segments of DNA) contain instructions for building the molecules, mostly proteins, that allow the human body to function. Genes of the parents are passed along to their offspring.

A genome is all of the genetic material in an organism and is made of DNA (or RNA in some viruses). It also includes genes and other elements that control the activity of those genes.

Does everyone have the same genome?

The genome in human beings is mostly the same, but for a 0.001% variation. This 0.001% variation contributes to the differences in health and appearance and are caused by the changes in the chemical tags that attach to DNA, thereby affecting the cells ability to read DNA’s instructions. These changes are called Epigenetic changes and are passed along the gene pool. It is a regular occurrence and can also be influenced by factors such as age, diseases, environment, lifestyle, etc.

Did you know that close relatives display similar characteristics because they share similar DNA?

Does genetic variation cause diseases or lead to health risk?

Most differences in DNA do not seem to have an effect on health or disease risk. Some variations can increase the likelihood of developing a certain disease. Similar to inherited traits, some diseases tend to cluster in families because these changes were inherited or passed along the gene pool from parent to offspring. Gene variations can also influence how people respond to certain medications.

Genetic Risk – Predisposition and Susceptibility

Genetic predisposition (also called genetic susceptibility) is the increased likelihood of developing a particular disease based on a person’s genetic makeup.

It does not mean that he / she will definitely develop the illness. In fact, some people who are at risk, never get the disease while others do, even within the same family. It only means that there is greater susceptibility or higher likelihood of developing it compared to those with no history of illness passed down genetically.

Each gene variation may only slightly increases a person’s risk, while several changes in different genes may combine to increase disease risk significantly. Diseases caused by multiple or a combination of factors are called multifactorial disorders.

Can Gene changes predict likely disorders?

Changes in many genes, each with a small effect, can lead to susceptibility to many common diseases such as cancer, diabetes, obesity, heart disease, and mental illness.

For example, certain mutations in the BRCA1 or BRCA2 genes can greatly increase a person’s risk of developing ovarian cancer and breast cancer, while variations in other genes, such as BARD1 and BRIP1 may also increase breast cancer risk.

However, it is to be noted that the contribution of these genetic changes to a person’s overall risk appears to be much smaller.

How can genetic risk be reduced?

Currently our genetic makeup cannot be altered (refer gene editing), but lifestyle, environmental changes and maintenance of healthy weight and diet can reduce the risk in people with a genetic predisposition.

Genetic tests can help identify the genetic variations that may indicate the risk of developing a specific disease or of passing a disease gene on to descendants. Genetic tests can also indicate how a person might respond to certain medicines.

Disease screenings can also detect potential diseases or health disorder, even before you start showing the symptoms.

Researchers are also focused on identifying genetic changes that have a small effect on disease risk but are common in the general population.

 

To know more about the Genome and gene editing, click here.

For more information and explanation of basic concepts of genetics, click here.

The Genetic Science Learning Center at the University of Utah provides more information about calculating the risk of genetic diseases and predicting disease based on family history.

Watch how gene predisposition affects Addiction and How Risks Unfolds Across the Lifespan

Author: Blog Desk
Blog Desk comprises many freelance medical and science writers with over a decade of experience in journalism. They have masters qualifications in journalism, science and management and have contributed significantly to the building of this portal. The authors can be contacted at blogdesk (at) skillmd (dot) com.

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