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Schilder’s Disease

Definition

Schilder’s disease is a rare progressive demyelinating disorder which usually begins in childhood. Schilder’s disease is not the same as Addison-Schilder disease (adrenoleukodystrophy). Symptoms may include dementia, aphasia, seizures, personality changes, poor attention, tremors, balance instability, incontinence, muscle weakness, headache, vomiting, and vision and speech impairment. The disorder is a variant of multiple sclerosis.

Prognosis

As with multiple sclerosis, the course and prognosis of Schilder’s disease are unpredictable. For some individuals the disorder is progressive with a steady, unremitting course. Others may experience significant improvement and even remission. In some cases, Schilder’s disease is fatal.

Treatment

Treatment for the disorder follows the established standards in multiple sclerosis and includes corticosteroids, beta-interferon or immunosuppressive therapy, and symptomatic treatment.

Source: https://www.ninds.nih.gov/

March 28, 2019
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